Designing metallodrugs with nuclease and protease activity.
Identifieur interne : 000214 ( Main/Exploration ); précédent : 000213; suivant : 000215Designing metallodrugs with nuclease and protease activity.
Auteurs : Caleb Mawuli Agbale [Brésil] ; Marlon Henrique Cardoso [Brésil] ; Isaac Kojo Galyuon [Ghana] ; Octávio Luiz Franco [Brésil]Source :
- Metallomics : integrated biometal science [ 1756-591X ] ; 2016.
Abstract
The accidental discovery of cisplatin some 50 years ago generated renewed interest in metallopharmaceuticals. Beyond cisplatin, many useful metallodrugs have been synthesized for the diagnosis and treatment of various diseases, but toxicity concerns, and the propensity to induce chemoresistance and secondary cancers make it imperative to search for novel metallodrugs that address these limitations. The Amino Terminal Cu(ii) and Ni(ii) (ATCUN) binding motif has emerged as a suitable template to design catalytic metallodrugs with nuclease and protease activities. Unlike their classical counterparts, ATCUN-based metallodrugs exhibit low toxicity, employ novel mechanisms to irreversibly inactivate disease-associated genes or proteins providing in principle, a channel to circumvent the rapid emergence of chemoresistance. The ATCUN motif thus presents novel strategies for the treatment of many diseases including cancers, HIV and infections caused by drug-resistant bacteria at the genetic level. This review discusses their design, mechanisms of action and potential for further development to expand their scope of application.
DOI: 10.1039/c6mt00133e
PubMed: 27714031
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000911
- to stream PubMed, to step Curation: 000910
- to stream PubMed, to step Checkpoint: 000910
- to stream Ncbi, to step Merge: 000A42
- to stream Ncbi, to step Curation: 000A42
- to stream Ncbi, to step Checkpoint: 000A42
- to stream Main, to step Merge: 000214
- to stream Main, to step Curation: 000214
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Designing metallodrugs with nuclease and protease activity.</title><author><name sortKey="Agbale, Caleb Mawuli" sort="Agbale, Caleb Mawuli" uniqKey="Agbale C" first="Caleb Mawuli" last="Agbale">Caleb Mawuli Agbale</name><affiliation wicri:level="2"><nlm:affiliation>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana and S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana and S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS</wicri:regionArea><placeName><region type="state">Mato Grosso do Sul</region></placeName></affiliation></author><author><name sortKey="Cardoso, Marlon Henrique" sort="Cardoso, Marlon Henrique" uniqKey="Cardoso M" first="Marlon Henrique" last="Cardoso">Marlon Henrique Cardoso</name><affiliation wicri:level="2"><nlm:affiliation>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF</wicri:regionArea><placeName><region type="state">District fédéral (Brésil)</region></placeName></affiliation></author><author><name sortKey="Galyuon, Isaac Kojo" sort="Galyuon, Isaac Kojo" uniqKey="Galyuon I" first="Isaac Kojo" last="Galyuon">Isaac Kojo Galyuon</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast</wicri:regionArea><wicri:noRegion>Cape Coast</wicri:noRegion></affiliation></author><author><name sortKey="Franco, Octavio Luiz" sort="Franco, Octavio Luiz" uniqKey="Franco O" first="Octávio Luiz" last="Franco">Octávio Luiz Franco</name><affiliation wicri:level="2"><nlm:affiliation>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF</wicri:regionArea><placeName><region type="state">District fédéral (Brésil)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27714031</idno><idno type="pmid">27714031</idno><idno type="doi">10.1039/c6mt00133e</idno><idno type="wicri:Area/PubMed/Corpus">000911</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000911</idno><idno type="wicri:Area/PubMed/Curation">000910</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000910</idno><idno type="wicri:Area/PubMed/Checkpoint">000910</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000910</idno><idno type="wicri:Area/Ncbi/Merge">000A42</idno><idno type="wicri:Area/Ncbi/Curation">000A42</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A42</idno><idno type="wicri:Area/Main/Merge">000214</idno><idno type="wicri:Area/Main/Curation">000214</idno><idno type="wicri:Area/Main/Exploration">000214</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Designing metallodrugs with nuclease and protease activity.</title><author><name sortKey="Agbale, Caleb Mawuli" sort="Agbale, Caleb Mawuli" uniqKey="Agbale C" first="Caleb Mawuli" last="Agbale">Caleb Mawuli Agbale</name><affiliation wicri:level="2"><nlm:affiliation>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana and S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana and S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS</wicri:regionArea><placeName><region type="state">Mato Grosso do Sul</region></placeName></affiliation></author><author><name sortKey="Cardoso, Marlon Henrique" sort="Cardoso, Marlon Henrique" uniqKey="Cardoso M" first="Marlon Henrique" last="Cardoso">Marlon Henrique Cardoso</name><affiliation wicri:level="2"><nlm:affiliation>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF</wicri:regionArea><placeName><region type="state">District fédéral (Brésil)</region></placeName></affiliation></author><author><name sortKey="Galyuon, Isaac Kojo" sort="Galyuon, Isaac Kojo" uniqKey="Galyuon I" first="Isaac Kojo" last="Galyuon">Isaac Kojo Galyuon</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast</wicri:regionArea><wicri:noRegion>Cape Coast</wicri:noRegion></affiliation></author><author><name sortKey="Franco, Octavio Luiz" sort="Franco, Octavio Luiz" uniqKey="Franco O" first="Octávio Luiz" last="Franco">Octávio Luiz Franco</name><affiliation wicri:level="2"><nlm:affiliation>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil. ocfranco@gmail.com and Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70719-100 Brasília, DF, Brazil and Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, 70910-900 Brasília, DF</wicri:regionArea><placeName><region type="state">District fédéral (Brésil)</region></placeName></affiliation></author></analytic><series><title level="j">Metallomics : integrated biometal science</title><idno type="eISSN">1756-591X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The accidental discovery of cisplatin some 50 years ago generated renewed interest in metallopharmaceuticals. Beyond cisplatin, many useful metallodrugs have been synthesized for the diagnosis and treatment of various diseases, but toxicity concerns, and the propensity to induce chemoresistance and secondary cancers make it imperative to search for novel metallodrugs that address these limitations. The Amino Terminal Cu(ii) and Ni(ii) (ATCUN) binding motif has emerged as a suitable template to design catalytic metallodrugs with nuclease and protease activities. Unlike their classical counterparts, ATCUN-based metallodrugs exhibit low toxicity, employ novel mechanisms to irreversibly inactivate disease-associated genes or proteins providing in principle, a channel to circumvent the rapid emergence of chemoresistance. The ATCUN motif thus presents novel strategies for the treatment of many diseases including cancers, HIV and infections caused by drug-resistant bacteria at the genetic level. This review discusses their design, mechanisms of action and potential for further development to expand their scope of application.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>Ghana</li></country><region><li>District fédéral (Brésil)</li><li>Mato Grosso do Sul</li></region></list><tree><country name="Brésil"><region name="Mato Grosso do Sul"><name sortKey="Agbale, Caleb Mawuli" sort="Agbale, Caleb Mawuli" uniqKey="Agbale C" first="Caleb Mawuli" last="Agbale">Caleb Mawuli Agbale</name></region><name sortKey="Cardoso, Marlon Henrique" sort="Cardoso, Marlon Henrique" uniqKey="Cardoso M" first="Marlon Henrique" last="Cardoso">Marlon Henrique Cardoso</name><name sortKey="Franco, Octavio Luiz" sort="Franco, Octavio Luiz" uniqKey="Franco O" first="Octávio Luiz" last="Franco">Octávio Luiz Franco</name></country><country name="Ghana"><noRegion><name sortKey="Galyuon, Isaac Kojo" sort="Galyuon, Isaac Kojo" uniqKey="Galyuon I" first="Isaac Kojo" last="Galyuon">Isaac Kojo Galyuon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000214 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000214 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaGhanaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27714031
|texte= Designing metallodrugs with nuclease and protease activity.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27714031" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SidaGhanaV1
| This area was generated with Dilib version V0.6.31. |  |